Buffalo Bills
| Week # | Date | Opponent | Results | Record | Streak | ||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sunday, Sep. 8 |
vs
Ari
| W 34-28 | 1-0-0 | Won 1 | J.Allen (232) | J.Cook (71) | K.Coleman (51) | Boxscore |
| 2 | Thursday, Sep. 12 |
@
Mia
| W 31-10 | 2-0-0 | Won 2 | T.Tagovailoa (145) | D.Achane (96) | D.Achane (69) | Boxscore |
| 3 | Monday, Sep. 23 |
vs
Jax
| W 47-10 | 3-0-0 | Won 3 | J.Allen (263) | J.Allen (44) | K.Shakir (72) | Boxscore |
| 4 | Sunday, Sep. 29 |
@
Bal
| L 35-10 | 3-1-0 | Lost 1 | L.Jackson (156) | D.Henry (199) | J.Hill (78) | Boxscore |
| 5 | Sunday, Oct. 6 |
@
Hou
| L 23-20 | 3-2-0 | Lost 2 | C.Stroud (331) | C.Akers (42) | S.Diggs (82) | Boxscore |
| 6 | Monday, Oct. 14 |
@
NYJ
| W 23-20 | 4-2-0 | Won 1 | A.Rodgers (294) | B.Hall (113) | A.Lazard (114) | Boxscore |
| 7 | Sunday, Oct. 20 |
vs
Ten
| W 34-10 | 5-2-0 | Won 2 | J.Allen (323) | R.Davis (41) | K.Coleman (125) | Boxscore |
| 8 | Sunday, Oct. 27 |
@
Sea
| W 31-10 | 6-2-0 | Won 3 | G.Smith (212) | G.Smith (16) | J.Smith-Njigba (69) | Boxscore |
| 9 | Sunday, Nov. 3 |
vs
Mia
| W 30-27 | 7-2-0 | Won 4 | J.Allen (235) | J.Cook (44) | R.Davis (70) | Boxscore |
| 10 | Sunday, Nov. 10 |
@
Ind
| W 30-20 | 8-2-0 | Won 5 | J.Flacco (272) | J.Taylor (114) | A.Pierce (81) | Boxscore |
| 11 | Sunday, Nov. 17 |
vs
KC
| W 30-21 | 9-2-0 | Won 6 | J.Allen (262) | J.Allen (55) | K.Shakir (70) | Boxscore |
| 13 | Sunday, Dec. 1 |
vs
SF
| W 35-10 | 10-2-0 | Won 7 | J.Allen (148) | J.Cook (107) | D.Knox (56) | Boxscore |
| 14 | Sunday, Dec. 8 |
@
LAR
| L 44-42 | 10-3-0 | Lost 1 | M.Stafford (320) | K.Williams (87) | P.Nacua (162) | Boxscore |
| 15 | Sunday, Dec. 15 |
@
Det
| W 48-42 | 11-3-0 | Won 1 | J.Goff (494) | J.Gibbs (31) | A.St. Brown (193) | Boxscore |
| 16 | Sunday, Dec. 22 |
vs
NE
| W 24-21 | 12-3-0 | Won 2 | J.Allen (154) | J.Cook (100) | J.Cook (26) | Boxscore |
| 17 | Sunday, Dec. 29 |
vs
NYJ
| W 40-14 | 13-3-0 | Won 3 | J.Allen (182) | J.Cook (53) | T.Shavers (69) | Boxscore |
| 18 | Sunday, Jan. 5 |
@
NE
| L 23-16 | 13-4-0 | Lost 1 | J.Milton III (241) | A.Gibson (41) | K.Boutte (117) | Boxscore |
| 19 | Sunday, Jan. 12 |
vs
Den
| W 31-7 | J.Allen (272) | J.Cook (120) | C.Samuel (68) | Boxscore | ||
| 20 | Sunday, Jan. 19 |
vs
Bal
| W 27-25 | J.Allen (127) | J.Cook (67) | K.Shakir (67) | Boxscore | ||
| 21 | Sunday, Jan. 26 |
@
KC
| L 32-29 | P.Mahomes (245) | K.Hunt (64) | X.Worthy (85) | Boxscore |