San Francisco 49ers
VS.
San Francisco 49ers
STAT
RANK
246.14
276.14
Passing yards per game
Dallas Cowboys
4
1
101.36
158.50
Rushing yards per game
Buffalo Bills
25
1
24.57
30.57
Points for per game
Detroit Lions
11
1
20.93
15.57
Points against per game
Buffalo Bills
75
1
12
24
Rushing touchdowns
Buffalo Bills
18
1
25
37
Passing touchdowns
Los Angeles Rams
6
1
37
55
Total touchdowns
Buffalo Bills
16
1
16
58
Sacks
Denver Broncos
32
1
446
514
Tackles
Pittsburgh Steelers
26
1
5
21
Interceptions
Chicago Bears
29
1
227.57
169.00
Opponent passing yards per game
Cleveland Browns
22
1
106.07
78.00
Opponent rushing yards per game
Tampa Bay Buccaneers
44
1
4-2-0
7-0-0
Home
Denver Broncos
13
1
6-2-0
6-0-0
Away
New England Patriots
3
1
4-1-0
5-0-0
Against division
Los Angeles Chargers
3
1
| Week # | Date | Opponent | Results | Record | Streak | |
|---|---|---|---|---|---|---|
| 5 | Thursday, Oct. 2 |
@
LAR
|
W 26-23 | 4-1-0 | Won 1 | Boxscore |
| 6 | Sunday, Oct. 12 |
@
TB
|
L 30-19 | 4-2-0 | Lost 1 | Boxscore |
| 7 | Sunday, Oct. 19 |
vs
Atl
|
W 20-10 | 5-2-0 | Won 1 | Boxscore |
| 8 | Sunday, Oct. 26 |
@
Hou
|
L 26-15 | 5-3-0 | Lost 1 | Boxscore |
| 9 | Sunday, Nov. 2 |
@
NYG
|
W 34-24 | 6-3-0 | Won 1 | Boxscore |
| 10 | Sunday, Nov. 9 |
vs
LAR
|
L 42-26 | 6-4-0 | Lost 1 | Boxscore |
| 11 | Sunday, Nov. 16 |
@
Ari
|
W 41-22 | 7-4-0 | Won 1 | Boxscore |
| 12 | Monday, Nov. 24 |
vs
Car
|
W 20-9 | 8-4-0 | Won 2 | Boxscore |
| 13 | Sunday, Nov. 30 |
@
Cle
|
W 26-8 | 9-4-0 | Won 3 | Boxscore |
| 15 | Sunday, Dec. 14 |
vs
Ten
|
W 37-24 | 10-4-0 | Won 4 | Boxscore |
December 17, 2025
| Adrian Martinez (QB) | Signed by the San Francisco 49ers to the practice squad. |
December 16, 2025
| Isaiah Bolden (CB) | Released by the San Francisco 49ers from the practice squad. |
December 15, 2025
| Jalen Graham (LB) | Reverted back to the San Francisco 49ers practice squad. |
| Sebastian Valdez (DT) | Reverted back to the San Francisco 49ers practice squad. |
December 13, 2025
| Brandon Aiyuk (WR) | Placed on the reserve/left squad list by the San Francisco 49ers. |
| Jalen Graham (LB) | Activated from the practice squad by the San Francisco 49ers. |
| Sebastian Valdez (DT) | Activated from the practice squad by the San Francisco 49ers. |