5:12 PM - Talanoa Hufanga (SF) (wrist) was placed on injured reserve Wednesday

4:58 PM - Talanoa Hufanga (SF) coach Kyle Shanahan said Tuesday that Hufanga has ligament damage in his wrist and will miss about a month, Matt Barrows of The Athletic reports.

5:25 PM - Talanoa Hufanga (SF) (wrist) has been ruled out for the rest of Sunday's game against the Cardinals, Eric Branch of the San Francisco Chronicle reports.

5:09 PM - Talanoa Hufanga (SF) (wrist) is considered questionable to return to Sunday's contest against the Cardinals, Nick Wagoner of ESPN.com reports.

7:56 PM - Talanoa Hufanga (SF) (ankle) was listed as a limited participant on the 49ers' injury report Thursday.

8:00 PM - Talanoa Hufanga (SF) (ankle) was a limited participant at the 49ers' practice Wednesday.

2:57 PM - Talanoa Hufanga (SF) (ankle) is inactive for Sunday's game against the Patriots, Matt Barrows of The Athletic reports.

11:42 AM - Talanoa Hufanga (SF) (knee) will be on a snap count Sunday against the Rams, David Lombardi of The San Francisco Standard reports.

6:48 PM - Talanoa Hufanga (SF) (knee) was listed as a full participant in Wednesday's practice session, Jenna Laine of ESPN.com reports.

12:04 PM - Talanoa Hufanga (SF) (knee) is listed as out for Sunday's game at the Vikings, Lindsey Pallares of the 49ers' official site reports.

4:07 PM - Talanoa Hufanga (SF) (knee) will be limited in practice Wednesday, Lindsey Pallares of the 49ers' official site reports.

7:10 PM - Talanoa Hufanga (SF) (knee) is out for Monday's game versus the Jets, Lindsey Pallares of the 49ers' official site reports.

4:58 PM - Talanoa Hufanga (SF) (knee) is listed as doubtful for Monday's game against the Jets, Eric Branch of the San Francisco Chronicle reports.

7:39 PM - Talanoa Hufanga (SF) (knee) practiced in limited fashion Friday, Nick Wagoner of ESPN.com reports.

7:16 PM - Talanoa Hufanga (SF) (knee) was a limited participant in practice Thursday, Adam Caplan of SiriusXM NFL Radio reports.

7:00 PM - Talanoa Hufanga (SF) coach Kyle Shanahan said Sunday that a decision will be made on whether Hufanga (knee) will begin the season on injured reserve, Lindsey Pallares of the 49ers' official site reports.

7:10 PM - Talanoa Hufanga (SF) (ACL) is sitting out of practice ahead of the 49ers' preseason finale at Las Vegas, Cam Inman of The San Jose Mercury News reports.

4:07 PM - Talanoa Hufanga (SF) Francisco head coach Kyle Shanahan said Saturday that he expects Hufanga (knee) to be back "in the next week or two," David Lombardi of The Athletic reports.

6:46 PM - Talanoa Hufanga (SF) 49ers placed Hufanga (knee) on the active/PUP list Tuesday, David Lombardi of Athletic reports.

12:09 PM - Talanoa Hufanga (SF) (knee) is expected to return to the mix "sometime in training camp," according to coach Kyle Shanahan, David Lombardi of The Athletic reports.

1:06 PM - Talanoa Hufanga (SF) Francisco head coach Kyle Shanahan confirmed Monday that Hufanga suffered a season-ending ACL tear to his right knee in Sunday's 27-14 win over the Buccaneers, Josh Dubow of the Associated Press reports.

6:13 PM - Talanoa Hufanga (SF) (knee) has been ruled out for the rest of Sunday's game against the Buccaneers, Lindsey Pallares of the 49ers' official site reports.

2:23 PM - Talanoa Hufanga (SF) recorded eight tackles (five solo) and an interception in Sunday's 34-3 win at the Jaguars.

1:00 PM - Talanoa Hufanga (SF) had 10 tackles (eight solo) in Sunday's 31-17 loss to the Bengals.

11:48 AM - Talanoa Hufanga (SF) had one solo tackle and and an interception in Thursday's 30-12 win over the Giants.

11:49 AM - Talanoa Hufanga (SF) notched five solo tackles, an interception and a pass defended in a 30-7 win over the Steelers on Sunday.

4:21 PM - Talanoa Hufanga (SF) (knee/personal) has been cleared to play Sunday against the Steelers, Nick Wagoner of ESPN.com reports.

6:25 PM - Talanoa Hufanga (SF) who has also been dealing with a knee injury, did not practice Thursday due to a personal matter, Nick Wagoner of ESPN.com reports.

2:45 PM - Talanoa Hufanga (SF) (knee) was a full participant at practice Monday, Nick Wagoner of ESPN.com reports.

5:13 PM - Talanoa Hufanga (SF) (knee) was a non-participant at Thursday's practice, Matt Maiocco of NBC Sports Bay Area reports.

5:49 PM - Talanoa Hufanga (SF) Francisco coach Kyle Shanahan said Saturday that Hufanga has a Baker's cyst in his knee but is expected to be available again in the coming days, David Lombardi of The Athletic reports.

11:32 AM - Talanoa Hufanga (SF) notched nine tackles (four solo) during Sunday's 37-34 win over the Raiders.

9:48 PM - Talanoa Hufanga (SF) logged nine tackles (six solo) and one forced fumble during Sunday's 13-0 win over the Saints

10:49 PM - Talanoa Hufanga (SF) tallied eight tackles (six solo) in Sundays 31-14 win against the Rams.

3:13 PM - Talanoa Hufanga (SF) (concussion) is listed as active Sunday against the Chiefs, Lindsey Pallares and Briana McDonald of the 49ers' official site report.

8:47 PM - Talanoa Hufanga (SF) (concussion) is considered questionable for Sunday's game against Kansas City, Matt Maiocco of NBC Sports Bay Area reports.

7:30 PM - Talanoa Hufanga (SF) (concussion) did not practice Thursday, Matt Maiocco of NBC Sports Bay Area reports.

4:20 PM - Talanoa Hufanga (SF) cleared to return after suffering a blow to the head during Sunday's loss at Atlanta, Hufanga entered concussion protocol Monday, Nick Wagoner of ESPN.com reports.

9:08 PM - Talanoa Hufanga (SF) recorded five tackles (two solo), one sack and one pass breakup during Sunday's 37-15 win over the Panthers.

3:08 PM - Talanoa Hufanga (SF) totaled a team-high 11 tackles (nine solo), as well as two tackles for loss and an interception in Sunday's 19-10 loss to Chicago.

3:08 PM - Talanoa Hufanga (SF) totaled a team-high 11 tackles (nine solo), as well as two tackles for loss and an interception in Sunday's 19-10 loss to Chicago.

10:20 AM - Talanoa Hufanga (SF) is one of several options who could start at strong safety alongside 49ers' veteran free safety, Jimmie Ward, this season.

3:20 PM - Talanoa Hufanga (SF) (knee) is inactive for Sunday's wild-card matchup against the Cowboys, Cam Inman of The San Jose Mercury News reports.

9:28 PM - Talanoa Hufanga (SF) (knee) is listed as questionable for Sunday's Wildcard matchup with the Cowboys.

6:07 PM - Talanoa Hufanga (SF) (knee) will not return Sunday against the Rams, Matt Barrows of The Athletic reports.

9:05 PM - Talanoa Hufanga (SF) (knee) logged a full practice Friday and has no injury designation for Sunday against the Rams, Jourdan Rodrigue of The Athletic reports.

2:59 PM - Talanoa Hufanga (SF) (knee) is inactive Sunday against the Texans, Keiana Martin of the 49ers' official site reports.

8:06 PM - Talanoa Hufanga (SF) (knee) is doubtful for Sunday against the Texans.

3:19 PM - Talanoa Hufanga (SF) (knee) has been ruled out for Thursday night's contest against the Titans, Cam Inman of The San Jose Mercury News reports.

1:35 PM - Talanoa Hufanga (SF) is dealing with a knee sprain and will be evaluated during the week, Eric Branch of the San Francisco Chronicle reports.

5:47 PM - Talanoa Hufanga (SF) (knee) has been ruled out of Sunday's game against the Falcons, according to Matt Maiocco of NBC Sports Bay Area.

5:13 PM - Talanoa Hufanga (SF) is questionable to return to Sunday's game against the Falcons due to a knee injury, Nick Wagoner of ESPN.com reports.

1:08 PM - Talanoa Hufanga (SF) is expected to start at strong safety in place off Jaquiski Tartt (knee) on Sunday, Nick Wagoner of ESPN.com reports.

3:39 PM - Talanoa Hufanga (SF) 49ers selected Hufanga in the fifth round of the 2021 NFL Draft, 180th overall.